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International Journal of Contemporary Research in Multidisciplinary

International Journal of Contemporary Research In Multidisciplinary, 2025;4(5):20-22

Macrocytic Anemia as the Initial Manifestation of Hypothyroidism in an Infant: A Case Report

Author Name: Dr. Sheikh Almas;   Dr. Sabavath Arun;   Dr. Kalyadapu Nikhil;   Dr. Pulendhar Reddy;  

1. MBBS, Osmania Medical College, Hyderabad, Telangana, India

2. MBBS, Osmania Medical College, Hyderabad, Telangana, India

3. MBBS, Osmania Medical College, Hyderabad, Telangana, India

4. MBBS, Osmania Medical College, Hyderabad, Telangana, India

Paper Type: case report
Article Information
Paper Received on: 2025-07-09
Paper Accepted on: 2025-08-23
Paper Published on: 2025-09-06
Abstract:

Hypothyroidism is a well-recognized cause of anemia in both children and adults, most often producing normocytic or microcytic anemia. Macrocytosis, however, is much less commonly encountered in hypothyroid states, especially in infancy, where nutritional deficiencies such as vitamin B12 or folate deficiency remain the foremost considerations. We report the case of an 8-month-old infant who presented with failure to thrive, developmental delay, and macrocytic anemia and was subsequently diagnosed with primary hypothyroidism. The case highlights the importance of considering endocrine disorders in the evaluation of unexplained macrocytosis, as timely thyroid hormone replacement can lead to complete haematological recovery in addition to improving neurodevelopmental outcomes.

Keywords:

Anemia, Congenital Hypothyroidism, Developmental delay

How to Cite this Article:

Dr. Sheikh Almas,Dr. Sabavath Arun,Dr. Kalyadapu Nikhil,Dr. Pulendhar Reddy. Macrocytic Anemia as the Initial Manifestation of Hypothyroidism in an Infant: A Case Report. International Journal of Contemporary Research in Multidisciplinary. 2025: 4(5):20-22


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