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International Journal of Contemporary Research in Multidisciplinary

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International Journal of Contemporary Research In Multidisciplinary, 2024;3(4):116-120

Is Umbilical Cord Blood Bilirubin a Reliable Predictor of Newborn Hyperbilirubinemia?

Author Name: Y Rohini;   MAK Satish;   Y Sunil Kumar;  

1. Lecturer in the Department of Biochemistry, Lenora Institute of Dental Sciences, Rajanagaram, Rajahmundry, Andhra Pradesh, India

2. Senior Lecturer in the Department of Anatomy, Lenora Institute of Dental Sciences, Rajanagaram, Rajahmundry, Andhra Pradesh, India

3. Senior Lecturer in the Department of Physics, SR College, Bhimavaram, Andhra Pradesh, India

Paper Type: research paper
Article Information
Paper Received on: 2024-05-16
Paper Accepted on: 2024-06-25
Paper Published on: 2024-08-01
Abstract:

Neonatal hyperbilirubinemia is the prevailing condition in newborns during the first week of life. Diagnosing substantial hyperbilirubinemia and initiating timely therapy in infants has become challenging due to early release following delivery. Therefore, there is a need to anticipate which newborns are at a high risk of developing hyperbilirubinemia. The motivation behind this study was to investigate whether the bilirubin level in the umbilical cord blood of neonates at birth could serve as a reliable indicator for predicting neonatal hyperbilirubinemia that would require phototherapy. This study utilized a cross-sectional design and included a sample of 208 babies who were healthy and born at full term (gestational age >37 weeks). The newborns were delivered in several hospitals located in Rajahmundry, Andhra Pradesh, India. The colorimetric Diazo technique was used to measure umbilical cord bilirubin (UCB). Hyperbilirubinemia was characterized by bilirubin levels that exceeded the recommended threshold for phototherapy, as outlined in the NICE guidelines. The mean umbilical cord blood (UCB) concentration in the newborns was 1.65±0.75 mg/dL. Approximately 39% of newborns necessitated phototherapy. The cutoff limit of UCB for identifying newborn hyperbilirubinemia was 1.975 mg/dL with an excellent sensitivity (76.54%) and specificity (87.4%). The receiver operating characteristic (ROC) curve demonstrated a high area under the curve (AUC) value of 0.879 for UCB in accurately identifying neonatal hyperbilirubinemia. The Youden measure demonstrated a satisfactory level of fairness in the current investigation. The prediction accuracy of the cutoff point of present study was likewise high. The findings of the current investigation demonstrated that the UCB is an excellent predictor of newborn hyperbilirubinemia and early identification of jaundice.

Keywords:

Neonatal hyperbilirubinemia; umbilical cord blood bilirubin; Diagnosis cutoff

How to Cite this Article:

Y Rohini, MAK Satish, Y Sunil Kumar. Is Umbilical Cord Blood Bilirubin a Reliable Predictor of Newborn Hyperbilirubinemia?. International Journal of Contemporary Research in Multidisciplinary. 2024: 3(4):116-120


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