Materia Medica is a cornerstone of Homoeopathic education, providing foundational knowledge for individualised patient care. Traditional teaching methods, predominantly lecture-based, have shown limitations in fostering critical thinking, retention, and practical application among undergraduate students. This study explores innovative teaching methodologies—including case-based learning, problem-based learning, digital simulations, and interactive workshops—to enhance understanding, clinical reasoning, and student engagement in Materia Medica education. Through field observations, structured student feedback, and evaluation of pilot teaching sessions, the study highlights the effectiveness, challenges, and feasibility of these approaches in contemporary Homoeopathic colleges. The findings support a blended teaching framework that combines traditional lectures with interactive, student-centred methods to produce competent and confident future practitioners.