International Journal of Contemporary Research In Multidisciplinary, 2025;4(5):20-22
Macrocytic Anemia as the Initial Manifestation of Hypothyroidism in an Infant: A Case Report
Author Name: Dr. Sheikh Almas; Dr. Sabavath Arun; Dr. Kalyadapu Nikhil; Dr. Pulendhar Reddy;
Abstract
Hypothyroidism is a well-recognized cause of anemia in both children and adults, most often producing normocytic or microcytic anemia. Macrocytosis, however, is much less commonly encountered in hypothyroid states, especially in infancy, where nutritional deficiencies such as vitamin B12 or folate deficiency remain the foremost considerations. We report the case of an 8-month-old infant who presented with failure to thrive, developmental delay, and macrocytic anemia and was subsequently diagnosed with primary hypothyroidism. The case highlights the importance of considering endocrine disorders in the evaluation of unexplained macrocytosis, as timely thyroid hormone replacement can lead to complete haematological recovery in addition to improving neurodevelopmental outcomes.
Keywords
Anemia, Congenital Hypothyroidism, Developmental delay
