International Journal of Contemporary Research in Multidisciplinary

Introduction: A prognostic factor makes it possible to predict the evolution of a disease and testifies to its aggressiveness and its extension. It is correlated with survival regardless of the treatment used.

Objective: This article aims to identify the prognostic factors in patients with colorectal cancer (CRC) in comparison with the literature.

Methods: The retrospective study was spread over five years, including 250 patients with locally advanced or metastatic CRC collected in the medical oncology department of the Pierre and Marie Curie center in Algiers. The factors studied were epidemiological, clinical, histological and biological. The overall survivals analysis was carried out according to the Kaplan Meier method, the estimation of the median survival with the comparisons of survival by the Long-Rang test (p < 0.05). The Cox regression has revealed the associated factors. The significance threshold was 0.05.

Results: The univariate analysis retained as prognostic factors, the personal and family history, the character and the seat of the tumor, the tumoral markers, and the type and under histological type, the vascular emboli and mitoses, the status KRAS and PIK3CA and the delay recurrences. In multivariate, the time to recurrence, the histological type and subtype, the vascular emboli, the ACE and the KRAS were retained.

Discussion: The prognostic factors of the CCR are numerous being able to be related to the patient, to the tumor, to the biological and molecular factors, of multiple interests allowing the estimation and the evaluation of the individual risk of the patients. They bring a precious help for the choice, therapy and monitoring.

Conclusion: The identification of prognostic factors is of capital interest in the therapeutic management of patients with CRC. Thus, well-conducted multivariate statistical studies will make it possible to precisely validate a prognostic factor.