IJ
IJCRM
International Journal of Contemporary Research in Multidisciplinary
ISSN: 2583-7397
Open Access • Peer Reviewed
Impact Factor: 5.67

International Journal of Contemporary Research In Multidisciplinary, 2026;5(4):478-489

From Psychopathology to Similimum: Clinical Phenotyping, Psychosomatic Profiling, Repertorial Mapping, And Homoeopathic Therapeutic Differentiation of Anxiety Disorders in Emerging Adulthood—A Systematic Review

Author Name: Prof. Dr. Niranjan Laxman Bhujbal;  

1. BHMS. M. D. Homoeopathy (Homoeopathic Psychiatry) PGDPC Professor and Head, Department of Practice of Medicine. Jagdamba Education Society’s Matoshri Asarabai Darade Homoeopathic and Medical College & Hospital Babhulgaon, Yeola, Nashik, Maharashtra, India

Abstract

Background: Anxiety disorders represent a heterogeneous group of mental health conditions characterised by excessive fear, apprehension, anticipatory worry, autonomic arousal, avoidance, and varying degrees of functional impairment. Emerging adulthood is a developmentally distinctive period marked by transitions in education, employment, relationships, financial independence, identity formation, and social roles. These transitions may interact with biological vulnerability, psychological traits, environmental stressors, and coping patterns to produce clinically diverse anxiety presentations. Homoeopathic clinical reasoning approaches such heterogeneity through individualisation, emphasising characteristic mental and physical symptoms, modalities, concomitants, causative factors, and the totality of the individual presentation. The evidentiary status of homoeopathy for anxiety disorders, however, remains uncertain.

Objective: To systematically examine the literature relevant to anxiety disorders in emerging adulthood and develop an evidence-informed conceptual framework connecting contemporary psychopathological characterisation, psychosomatic manifestations, clinical phenotypes, repertorial constructs, and traditional homoeopathic therapeutic differentiation.

Methods: The review was designed according to PRISMA 2020 principles. Electronic searches were structured for PubMed/MEDLINE, Scopus, Web of Science, PsycINFO, Google Scholar, and relevant complementary-medicine databases. Search concepts included anxiety disorders, generalised anxiety disorder, panic symptoms, emerging adulthood, young adults, psychosomatic manifestations, homeopathy/homoeopathy, individualised treatment, repertory, and materia medica. Contemporary psychiatric and clinical literature was considered alongside peer-reviewed homoeopathic clinical research. Classical homoeopathic sources were used only to contextualise traditional therapeutic differentiation and were not treated as evidence of clinical efficacy. Because of anticipated heterogeneity in populations, interventions, diagnostic criteria, outcome measures, and study designs, a structured narrative synthesis was planned.

Results: Contemporary literature conceptualises anxiety as a multidimensional phenomenon involving cognitive, emotional, autonomic, behavioural, somatic, and functional domains. Emerging adults may present with anticipatory worry, performance anxiety, health concerns, sleep disturbance, gastrointestinal symptoms, palpitations, tremulousness, muscular tension, avoidance, and impaired academic, occupational, or interpersonal functioning. Published homoeopathic evidence specific to anxiety disorders is sparse and methodologically heterogeneous. A placebo-controlled pilot study of individualised homoeopathic treatment for generalised anxiety disorder reported no statistically significant between-group advantage on its primary GAD-7 outcome, although a secondary HAM-A outcome favored the individualised treatment group. Earlier systematic-review evidence likewise did not establish reliable efficacy. A phenotype-to-similimum framework may nevertheless provide a testable method for organising individualised homoeopathic prescribing variables in future research.

Conclusion: Clinical phenotyping and psychosomatic profiling provide a potentially useful bridge between conventional diagnostic classification and the individualised descriptive framework used in homoeopathic practice. The resulting repertorial and materia medica differentiation should be interpreted as a framework for hypothesis generation rather than evidence of therapeutic efficacy. Future adequately powered, prospectively registered, independently replicated randomised controlled trials using standardised diagnostic procedures, validated outcome measures, transparent repertorial methods, and rigorous reporting are required.

Keywords

anxiety disorders, generalised anxiety disorder, emerging adulthood, clinical phenotyping, psychosomatic symptoms, homoeopathy, repertory; similimum, individualised medicine, systematic review.