The philosophical foundation of homoeopathy, as established by Samuel Hahnemann in the Organon of Medicine, presents a dynamic understanding of health, disease, and vital processes. Modern human physiology explains bodily mechanisms through biochemical, neuro-endocrine, and immunological pathways, whereas homoeopathic philosophy interprets these functions through the concept of the vital force. This analytical review examines selected aphorisms from the Organon in relation to contemporary human physiology and comparatively evaluates the interpretations of James Tyler Kent, Cyrus Maxwell Boger, Ernest Albert Farrington, and Clemens von Boenninghausen. The review identifies conceptual correlations between physiological regulation and homoeopathic principles such as susceptibility, dynamic disturbance, miasmatic influence, and individualisation. Comparative interpretation demonstrates that Kent emphasised spiritual and dynamic physiology, Boger focused on pathological evolution and constitutional response, Farrington correlated symptomatology with clinical physiology, while Boenninghausen emphasised modalities and systemic functional relationships. The study concludes that physiological understanding enhances interpretative clarity of Organon aphorisms and strengthens clinical reasoning in homoeopathic practice.