International Journal of Contemporary Research In Multidisciplinary, 2026;5(2):895-901
Econazole: Advances in Pharmacology, Formulation Strategies, And Clinical Applications
Author Name: Rohit Saini; Jitendra Singh Yadav; Sachin Rathod; Pabitra Panigrahi;
Abstract
Fungal infections remain a major global health concern, affecting millions of individuals annually, particularly in tropical and subtropical regions. Superficial mycoses such as dermatophytosis and candidiasis represent a significant burden in developing countries, including India. Among topical antifungal agents, Econazole nitrate has been extensively utilised due to its broad-spectrum antifungal activity, favourable safety profile, and additional antibacterial properties. This review comprehensively discusses the chemistry, pharmacology, mechanism of action, pharmacokinetics, and spectrum of activity of econazole. Furthermore, conventional and advanced formulation approaches—including vesicular systems, nanotechnology-based carriers, and gel-based platforms—are critically analysed. Clinical applications, comparative efficacy, safety considerations, and future research perspectives are also explored. The review highlights the need for innovative drug delivery systems strategies to enhance therapeutic performance and patient compliance.
Keywords
Econazole, Imidazole antifungal, Topical delivery, Nanocarriers, Dermatophytosis.