International Journal of Contemporary Research In Multidisciplinary, 2025;4(6):519-523
A Review on Role of Lithium in Alzheimers Disease
Author Name: Dr. Hema Manogna Narne; Halaharvi Tippareddy Gari Divya Sri; Raj Kumar Tirupathi Reddy Macha; Thoka Nivedha; Budati Deepika Lakshmi; Tenali Keerthana; Lakshmi Keerthi Thumma;
Paper Type: review paper
Article Information
Abstract:
Alzheimer’s disease (AD) is characterised by amyloid accumulation, tau hyperphosphorylation, and progressive cognitive decline. Emerging evidence suggests that lithium, even at trace levels, supports neuronal survival by modulating GSK-3β, enhancing neurogenesis, reducing inflammation, and stabilising mitochondria. Epidemiological and experimental studies indicate that lithium deficiency may increase AD risk, while microdose lithium shows promise in improving cognition and reducing pathology with minimal toxicity. This review summarises current findings linking lithium deficiency to AD and highlights its potential as a preventive neuroprotective strategy.
Keywords:
Lithium, Alzheimer’s disease, Neuroprotection, Amyloid-β, Microdose lithium, Neuroinflammation, Neurogenesis, Mitochondrial dysfunction, Cognitive decline, Environmental lithium exposure.
How to Cite this Article:
Dr. Hema Manogna Narne,Halaharvi Tippareddy Gari Divya Sri,Raj Kumar Tirupathi Reddy Macha,Thoka Nivedha,Budati Deepika Lakshmi,Tenali Keerthana,Lakshmi Keerthi Thumma. A Review on Role of Lithium in Alzheimers Disease. International Journal of Contemporary Research in Multidisciplinary. 2025: 4(6):519-523
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