Background: Urolithiasis (renal stone disease) remains a prevalent disorder of the urinary tract with multifactorial aetiology. Conventional management involves analgesia, hydration, and surgical or lithotripsy interventions, but recurrence rates remain high. Homoeopathy provides individualized, non-invasive therapy aiming to relieve pain, promote calculi expulsion, and correct metabolic predisposition.

Case Presentation: A 35-year-old male presented with recurrent left renal colic, dysuria, and hematuria. Ultrasonography revealed a 6.2 mm calculus in the lower calyx of the left kidney with mild hydronephrosis. The patient was treated with individualised Homoeopathic medicines—Berberis vulgaris Q and Lycopodium clavatum 30C—selected on the totality of symptoms. Clinical improvement occurred within 4 weeks, and repeat ultrasonography after 8 weeks confirmed complete expulsion of the calculus.

Conclusion: This case demonstrates successful non-surgical management of urolithiasis using individualised Homoeopathic remedies, supporting the need for larger observational trials.