International Journal of Contemporary Research in Multidisciplinary

Diabetes mellitus (DM) is a chronic, progressive metabolic disorder marked by persistent hyperglycemia due to defects in insulin secretion, insulin action, or both. Insulin, a vital hormone produced by the pancreas, facilitates the uptake of glucose into cells and helps maintain blood glucose homeostasis. When insulin production is insufficient or its action is impaired, glucose accumulates in the bloodstream, leading to elevated blood sugar levels. Over time, this imbalance can result in serious and potentially irreversible complications affecting multiple organ systems, including the heart, kidneys, eyes, nerves, and blood vessels.
Diabetes is generally classified into two main types: Type 1, characterized by autoimmune destruction of pancreatic beta cells, and Type 2, which involves insulin resistance and relative insulin deficiency. Both types present with common symptoms such as excessive thirst, frequent urination, unexplained weight loss, fatigue, and blurred vision. If not diagnosed and managed early, diabetes can lead to long-term health issues such as cardiovascular diseases, nephropathy, retinopathy, and neuropathy. The global burden of diabetes is increasing at an alarming rate, with projections indicating a possible doubling of cases in the coming decades. Early diagnosis through blood glucose testing and glycosylated hemoglobin (HbA1c) measurement is crucial for timely intervention. Management strategies typically involve lifestyle modifications, dietary regulation, regular physical activity, and pharmacological therapies including insulin and oral hypoglycemics. This paper provides a detailed examination of the pathophysiology, symptoms, diagnostic methods, complications, and comprehensive management approaches associated with diabetes mellitus.