International Journal of Contemporary Research in Multidisciplinary

Diabetes mellitus is a metabolic disorder of carbohydrate metabolism. NIDDM or type 2 diabetes comprises 90% of all people in developed and developing countries. NIDDM is characterized by hyperglycemia and other metabolic and pathological complications due to glucose intolerance. The glucose intolerance and auto-oxidation of glucose is the main source of free radical formation which plays a very important role in the development of complications of diabetes. Various methods have been employed to treat diabetes mellitus, including dietary modifications and the use of certain medicinal plants. The seed of Carum copticum (Ajowan) has been described in the old literature of Ayurvedic and Unani systems of medicine to possess many medicinal characteristics, including hypocholesterolemic, hypotriglyceridemic, and hypophosphatemic effects in four weeks of trial in normal albino rabbits. In light of the above, the present study aimed to evaluate the effect of feeding Carum copticum seed powder on the levels of oxidative stress in NIDDM patients of the 30-60 years of age group. The mean ± SD values of fasting plasma glucose and malondialdehyde were measured before the drug trial i.e., at the 0th day, 15th day, 30th day, 60th day of the drug trial period, and the 15th day of drug withdrawal. A significant (p<0.001) decline in the levels of malondialdehyde was observed throughout the drug trial period and the 15th day of the drug withdrawal.