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International Journal of Contemporary Research in Multidisciplinary

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International Journal of Contemporary Research In Multidisciplinary, 2024;3(3):162-169

Anti Tumorous Effect of Synthesized Vincristine Hydrogel Scaffolds on Transmissible Venereal Granuloma in Canine

Author Name: Arun Kumar;   Narendra Singh Jadon;   M. G. H. Zaidi;   Manjul Kandpal;   Rashmi Saini;  

1. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science, G. B. Pant University of Agriculture and Technology, Pant agar, Uttarakhand, India

2. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science, G. B. Pant University of Agriculture and Technology, Pant agar, Uttarakhand, India

3. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science, G. B. Pant University of Agriculture and Technology, Pant agar, Uttarakhand, India

4. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science, G. B. Pant University of Agriculture and Technology, Pant agar, Uttarakhand, India

5. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science, G. B. Pant University of Agriculture and Technology, Pant agar, Uttarakhand, India

Abstract

Vincristine is considered a first-line chemotherapy drug for the treatment of venereal tumour (CTVT). There are many types of encapsulated antitumor drugs used to treat tumors, with increased drug solubility, better bioavailability, high stability, drug release, extended half-life, selective internal organs or tissues, and overall reduced dosage. Therefore, the aim of this study was to evaluate the antitumor safety of vincristine and its scaffold, which can be quickly and safely affected by many clinical physiological and blood biochemical parameters before and after treatment of infectious veneral tumors in dogs.The oncolytic effect of vincristine and its scaffolds was demonstrated using clinical methods and ability effects and histopathological changes in the tumor body and oncolytic effect at 0, 1, 2, 3 and 4 weeks. Dogs with CTVT used in this study (n = 12) were divided into two groups regardless of gender. Control group (A-vincristine; n=6) and experimental group (B-vincristine scaffold; n=6). Animals in groups A and B were injected with 0.025 mg/kg body weight of vincristine sulfate once a week for four consecutive weeks, and 0.025 mg/kg of vincristine sulfate was scaffolds injected once a week for four consecutive weeks. In conclusion, the use of vincristine hydrogel scaffolds is useful and effective in the treatment of CTVT.

Keywords

Vincristine sulphate, hydrogel scaffolds, CTVT and apoptosis