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International Journal of Contemporary Research in Multidisciplinary

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International Journal of Contemporary Research In Multidisciplinary, 2024;3(3):140-147

Transmissible Venereal Granuloma Invasiveness and Response to Chemotherapeutics in Canine

Author Name: Arun Kumar;   Narendra Singh Jadon;   M. G. H. Zaidi;   Manjul Kandpal;   Rashmi Saini;  

1. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science G. B. Pant University of Agriculture and Technology, Pant Nagar, Uttarakhand, India

2. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science G. B. Pant University of Agriculture and Technology, Pant Nagar, Uttarakhand, India

3. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science G. B. Pant University of Agriculture and Technology, Pant Nagar, Uttarakhand, India

4. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science G. B. Pant University of Agriculture and Technology, Pant Nagar, Uttarakhand, India

5. Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Science G. B. Pant University of Agriculture and Technology, Pant Nagar, Uttarakhand, India

Abstract

The main aim of this study is to compare the chemotherapeutic effect of vincristine sulfate hydrogel scaffolds and cisplatin hydrogel scaffolds on canine transmissible venereal granuloma. The safety and anti-cancer properties of the scaffold were evaluated by various clinical and biochemical blood parameters before and after treatment of canine transmissible tumor (CTVT). The 12 dogs with canine infectious tumors used in this study were divided into two groups, regardless of gender. A and B. Animals in groups A and B received 0.025 mg/kg vincristine sulfate stent injection and 2.14 mg/kg cisplatin scaffold intravenously per week for four weeks and were repeated 21 days later. To evaluate the response to chemotherapeutic drugs, physical appearance, histopathological changes and blood biochemical parameters related to oncolytic effect were examined at week zero, first, second, third and fourth using standard procedures. Based on the limitations of this study, it was determined that the level of apoptosis was higher in the CTVT cells in the first and second week of the animals applied to the vincristine sulfate scaffold compared to the cisplatin scaffold, according to the symptoms and histopathological examination. Vincristine sulfate hydrogel scaffold was more effective due to tumor regeneration compared to cisplatin hydrogel scaffold.

Keywords

Vincristine sulphate, hydrogel scaffolds, CTVT and Cisplatin